肝纤维化(HF)是慢性肝损伤的病理生理结果,其特征是细胞外基质蛋白的过度积累.现有多项研究证实转化生长因子-β1(TGF-β1)及其下游Smad家族形成的信号通路在HF发生发展中具有重要意义,以此通路为靶点的中医药研究是目前逆转HF的热点.因此,本文以TGF-β1/Smads信号通路为切入点,综述近几年中药复方及单味药提取物干预TGF-β1/Smads通路及通路上下游相关因子逆转HF的作用机制,揭示中医药的靶向治疗作用,为阐明中医药的作用机制提供新策略.
Hepatic fibrosis(HF)is a pathophysiological outcome of chronic liver injury and is characterized by excessive accumulation of extracellular matrix protein.A number of studies have confirmed that the signaling pathways formed by transforming growth factor-β1(TGF-β1)and its downstream Smad family play an important role in the occurrence and development of HF,and the traditional Chinese medicine(TCM)research targeting this pathway is currently a hot spot in the reversal of HF.Therefore,taking TGF-β1/Smads signaling pathway as the entry point,this paper reviewed the mechanism of action of TCM compound formula and single drug extract in intervening TGF-β1/Smad pathway and related factors upstream and downstream of the pathway to reverse HF in recent years,revealed the targeted therapeutic effect of TCM,and provided new strategies for clarifying the mechanism of TCM.
陶永彪;杨世睿;汪龙德;吴亚娜;张志明;李赋
甘肃中医药大学中医临床学院,甘肃兰州 730020甘肃省中医药大学附属医院脾胃病科,甘肃兰州 730020甘肃省中医院肿瘤科,甘肃兰州 730020
中医学
中医药;肝纤维化;转化生长因子-β1/Smads信号通路
traditional Chinese medicine;hepatic fibrosis;transforming growth factor-β1/Smads signaling pathway
《中国临床药理学杂志》 2024 (006)
918-922 / 5
甘肃省中西医结合肿瘤临床医学研究中心课题基金资助项目(18JR2FA001);甘肃省名中医传承工作室建设项目(国中药规财函[2021]242)
10.13699/j.cnki.1001-6821.2024.06.028
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