目的 探讨炎症因子、凝血指标和糖类抗原125(CA125)在中重度卵巢子宫内膜异位囊肿的临床意义及诊断价值.方法 回顾性分析2021年1-12月深圳市第二人民医院收治的Ⅲ、Ⅳ期卵巢子宫内膜异位囊肿患者127例(内异症组)和卵巢其他良性囊肿患者101例(对照组)的临床资料,比较两组患者的炎症因子、凝血功能和CA125的差异,绘制受试者工作特征(ROC)曲线,分析相关指标对中重度卵巢子宫内膜异位囊肿的诊断价值.结果 内异症组患者中性粒细胞计数/淋巴细胞计数(NLR)和血小板计数/淋巴细胞计数(PLR)均显著高于对照组(P＜0.05);血浆纤维蛋白原(FIB)显著高于对照组(P＜0.05);凝血酶时间(TT)显著短于对照组(P＜0.05);CA125和人附睾蛋白4(HE4)均显著高于对照组(P＜0.05);两组间淋巴细胞计数/单核细胞计数(LMR)、血小板计数(PLT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)差异无统计学意义(P＞0.05).CA125及NLR联合检测可提高诊断的敏感度至89.0％.结论 中重度卵巢子宫内膜异位囊肿患者存在炎症因子改变和FIB增高,CA125及NLR联合检测在临床上具有一定价值.
Objective To explore the clinical significance and diagnostic value of inflammatory factors,coagula-tion and carbohydrate antigen 125(CA125)in moderate to severe ovarian endometriosis cyst.Methods A retrospective analysis was conducted on clinical data from 127 patients with stage Ⅲ and Ⅳ ovarian endometriotic cysts(endometriosis group)and 101 patients with other benign ovarian cysts treated at Shenzhen Second People's Hospital from January to De-cember,2021.The differences in inflammatory factors,coagulation function,and CA125 between the two groups were compared.Receiver operating characteristic(ROC)curves were drawn,and the diagnostic value of relevant indicators for moderate to severe ovarian endometriosis was analyzed.Results In the endometriosis group,the neutrophil-to-lym-phocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)were significantly higher than those in the control group(P＜0.05).Plasma fibrinogen(FIB)was significantly higher in the endometriosis group(P＜0.05).Thrombin time(TT)was significantly shorter in the endometriosis group(P＜0.05).CA125 and human epididymis protein 4(HE4)were significantly higher in the endometriosis group(P＜0.05).There were no significant differences between the two groups in lymphocyte-to-monocyte ratio(LMR),platelet count(PLT),prothrombin time(PT),and activated partial thromboplastin time(APTT)(P＞0.05).Combined detection of CA125 and NLR can increase the sensitivity of diagnosis to 89.0％.Conclusion Patients with moderate to severe ovarian endometriosis exhibit changes in inflammatory factors and elevated fibrinogen.Combined detection of CA125 and NLR has clinical value in the diagnosis of moderate to severe ovarian endometriosis.
李蕾;张晓露;闫泓霖;洪波;黄燕宇
深圳市第二人民医院妇科(广东深圳 518000)深圳市宝安区人民医院妇科(广东深圳 518000)
临床医学
中重度子宫内膜异位囊肿;纤维蛋白原;血小板;炎症因子;糖类抗原125
ovarian endometriosis cyst;fibrinogen;platelet;inflammatory factors;CA125
《广东医学》 2024 (003)
366-370 / 5
深圳市科技计划项目(JCYJ20210324103001003)
10.13820/j.cnki.gdyx.20232767
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