妊娠早期血清尿三氯生水平与妊娠28周血糖稳态的关系OACSTPCD

Objective To investigate the correlation between urinary triclosan(TCS)levels in early pregnancy and glucose homeostasis at 28 weeks of gestation.Methods A total of 241 pregnant women undergoing prenatal exami-nations at the Second Central Hospital of Baoding from January 2019 to June 2020 were recruited.The primary outcome was gestational diabetes mellitus(GDM)screened by a 1-hour non-fasting,50 g glucose load test(GLT)at a median of 28 weeks of pregnancy.Urine samples were collected in early and mid-pregnancy to measure urine specific gravity(Sg)and quantify phenolic compounds(bisphenol A,benzophenone-3,and TCS)using online solid-phase extraction combined with isotope dilution-high-performance liquid chromatography-tandem mass spectrometry.Results Ac-cording to GLT results,199 women had normal GLT,while the remaining 42 had abnormal results.Women with abnormal GLT had higher BMI and lower total exercise time compared to those with normal GLT(P＜0.05).Positive associations between TCS levels and gestational glucose levels were observed in early pregnancy and mid-pregnancy(comparing the 2nd,3rd,and 4th quartiles with the 1st quartile of TCS:adj.OR=0.41,95％CI:-0.19-1.05;adj.OR=0.43,95％CI:-0.17-1.02;adj.OR=0.45,95％CI:-0.14-1.05)and mid-pregnancy(adj.OR=0.76,95％CI:0.19-1.32;adj.OR=0.66,95％CI:0.94-1.22;adj.OR=0.56,95％CI:0.04-1.12).Bayesian kernel ma-chine regression(BKMR)results indicated a positive association between TCS and glucose levels in both early and mid-pregnancy(P＜0.05).Conclusion Urinary TCS concentration during pregnancy is positively correlated with glucose levels in late pregnancy GDM screening tests.