As pancreatic cancer(PC)is highly malignant,its patients tend to develop metastasis at an early stage and show a poor response to conventional chemotherapies.First-line chemotherapies for PC,according to current guidelines,include fluoropyrimidine-and gemcitabine-based regimens.Accumulating research on drug resistance has shown that biochemical metabolic aberrations in PC,especially those involving glycolysis and glutamine metabolism,are highly associated with chemoresistance.Additionally,lipid metabolism is a major factor in chemoresistance.However,emerging compounds that target these key metabolic pathways have the potential to overcome chemoresistance.This review summarizes how PC develops chemoresistance through aberrations in biochemical metabolism and discusses novel critical targets and pathways within cancer metabolism for new drug research.
Jingcheng Zhang;Yutong Wang;Lejunzi Wang;Lei You;Taiping Zhang
Department of General Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China||Peking Union Medical College,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,ChinaPeking Union Medical College,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,ChinaDepartment of Anaesthesia,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,ChinaDepartment of General Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,ChinaDepartment of General Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China||Clinical Immunology Centre,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China
Pancreatic cancer;Drug resistance;Drug development;Signal transduction
《中华医学杂志（英文版）》 2024 (004)
408-420 / 13
This study was supported by grants from the National Natural Science Foundation of China(Nos.81772639 and 81802475)and Natural Science Foundation of Beijing(No.7192157).
10.1097/CM9.0000000000002758
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