过去20年中,代谢障碍相关性脂肪性肝病(MAFLD)的全球发病率急剧上升,影响着全球30％以上的人口.同时,过去40年全球肝内胆管癌(ICC)的发病率也增长了140％.此外,既往研究表明,多种形式的肝脏炎症都与ICC发生发展密切相关.这提示MAFLD在ICC的发生、发展及预后等方面可能起着重要作用.本文旨在梳理MAFLD相关ICC的研究现状,回顾现有研究的不足之处,并展望未来的研究方向,为相关研究的进一步开展和深入提供基础.
Over the past 20 years,the global incidence of metabolic dysfunction-associated fatty liver disease(MAFLD)has increased dramatically,affecting more than 30％of the global population.Meanwhile,over the past 40 years,the global incidence of intrahepatic cholangiocarcinoma(ICC)has also grown by 140％.In addition,previous studies have indicated that various forms of liver inflammation are closely associated with the occurrence and development of ICC.This suggests that MAFLD may play an important role in the occurrence,development,and prognosis of ICC.This article aims to summarize the current research status of MAFLD-related ICC,review the shortcomings in existing studies,and outline future research directions to provide a foundation for further exploration and in-depth study in this field.
李宗龙;陈家璐;唐玥;覃德龙;汤朝晖;全志伟
上海交通大学医学院附属新华医院普通外科,上海 200092
临床医学
胆管肿瘤;胆管,肝内;代谢障碍相关性脂肪性肝病
Bile Duct Neoplasms;Bile Ducts,Intrahepatic;Metabolic Dysfunction-Associated Fatty Liver Disease
《中国普通外科杂志》 2024 (002)
176-183 / 8
国家自然科学基金资助项目(81772521);上海交通大学医学院附属新华医院院级临床研究培育基金资助项目(17CSK06);上海交通大学医学院多中心临床研究基金资助项目(DLY201807).
10.7659/j.issn.1005-6947.2024.02.003
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