二乙氨基硫代甲酸铜[copper diethyldithiocarbamate,Cu(DDC)2]可通过多种机制诱导肿瘤细胞死亡,是一种潜在的抗肿瘤药物.但Cu(DDC)2 极低的水溶性使其应用受到很大限制.Cu(DDC)2 纳米给药系统在细胞和动物模型中显示出良好的抗肿瘤作用.文章基于近年来关于Cu(DDC)2 纳米给药系统的抗肿瘤研究进行总结和展望,为新型Cu(DDC)2 纳米给药系统的设计提供参考.
Copper diethyldithiocarbamate[Cu(DDC)2]can induce tumor cell death through various mechanisms,which is a potential anti-tumor drug.However,the extremely low water solubility of Cu(DDC)2 greatly limits its application.Cu(DDC)2 nanomedicine delivery systems have shown good anti-tumor effects in both cellular and animal models.This paper was based on recent anti-tumor research on Cu(DDC)2 nanomedicine delivery systems,summarizing and looking forward to providing reference for the design of new Cu(DDC)2 nanomedicine systems.
潘雪飞;王劲;陈晓蕾;沈奇英
杭州师范大学药学院,浙江 杭州 311121
药学
Cu(DDC)2;纳米给药系统;抗肿瘤
Cu(DDC)2;nanomedicine delivery system;anti-tumor
《杭州师范大学学报（自然科学版）》 2024 (002)
124-131 / 8
浙江省医药卫生科技计划青年人才项目(2022RC241);浙江省医药卫生科技计划一般项目(2024KY236);国家级大学生创新创业训练计划项目(202310346080);2023年杭州师范大学教学改革项目.
10.19926/j.cnki.issn.1674-232X.2023.10.231
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