目的 深度挖掘中医药治疗重症急性胰腺炎(SAP)致急性肺损伤(ALI)的组方规律.方法 通过计算机检索中国期刊全文数据库、中文期刊全文数据库、万方数据知识服务平台,构建中医药治疗SAP致ALI数据库,采用中医传承计算平台V 3.0 分析其用药、组方规律.结果 共筛选到方剂 23 首,涉及药物 39 味,其中使用频次较高的药物有大黄、芒硝、黄芩、木香、厚朴、柴胡、枳实等;用药以泻下类、清热类及理气类为主;药性以寒性为主,药味以苦、辛为主;归经以脾、胃、大肠、肺经为主;常用药对有大黄-芒硝、大黄-黄芩、大黄-芒硝-黄芩、芒硝-黄芩、大黄-木香、芒硝-木香、大黄-芒硝-木香、大黄-厚朴、大黄-柴胡、大黄-枳实、芒硝-柴胡、大黄-芒硝-柴胡等;聚类分析得到类方组合3 个.结论 "腑气不通,上乘于肺"是SAP致ALI的主要病机,"肺与大肠相表里",肺肠合治是中医药治疗SAP致ALI的重要方法,方剂多以大承气汤为基础方,功效以通腑泄浊为主,兼以行气,能降低患者病死率,提高临床疗效.
Objective To explore the rule of Chinese medicine in treating acute lung injury(ALI)caused by severe acute pancreatitis(SAP).Methods Through computer retrieval of Chinese journal full-text database,Chinese journal full-text database and Wanfang data knowledge service platform,the database of TCM treatment SAP to ALI was constructed.The traditional Chinese medicine inheritance computing platform V 3.0 was used to analyze the rules of medication and prescription composition.Results A total of 23 prescriptions were screened,including 39 herbs,among which Rhubarb,Mirabilite,Scutellaria baicalensis,Radices saussureae,Magnolia hypoleuca,Bupleurum,Fructus aurantii immaturus were frequently used.The main drugs are purging,clearing heat and regulating qi.The medicinal properties are mainly cold,and the taste is mainly Bitterness and Simba.The main channels are spleen,stomach,large intestine and lung.Common drugs include Rhubarb-Mirabilite,Rhubarb-Scutellaria baicalensis,Rhubarb-Mirabilite-Scutellaria baicalensis,Mirabilite-Scutellaria baicalensis,Rhubarb-Radices saussureae,Mirabilite-Radices saussureae,Rhubarb-Mirabilite-Radices saussureae,Rhubarb-Magnolia hypoleuca,Rhubarb-Bupleurum,Rhubarb-Fructus aurantii immaturus,Mirabilite-Bupleurum,Rhubarb-Mirabilite-Bupleurum.Three square combinations were obtained by cluster analysis.Conclusion"relieving gas impassability,excellent in lung"is the main pathogenesis of acute pancreatitis and acute lung injury,"The Lung And The Large Intestine Are Interior-Exteriorl",so"combined treatment of lung and intestine"is the important methods for the treatment of acute pancreatitis and acute lung injury by Chinese traditional medicine,more prescriptions on the basis of Dachengqi Decoction,the effect is mainly to eliminate turbidity by purgation,and to regulate qi,can reduce the mortality of patients and improve the clinical efficacy.
严晓;宋洋;金伟;张晓云
成都中医药大学临床医学院,成都 610075成都中医药大学附属医院急诊科,成都 610036
临床医学
重症急性胰腺炎;急性肺损伤;中医药;数据挖掘;中医传承计算平台;肺肠合治
Severe acute pancreatitis;Acute lung injury;Traditional Chinese medicine;Data mining;TCM inheritance computing platform system;Combined treatment of lung and intestine
《中国药物经济学》 2024 (002)
38-42,46 / 6
成都中医药大学"杏林学者"学科人才科研提升计划(ZRQN2020009);成都中医药大学"杏林学者"学科人才科研提升计划(苗圃人才专项)(MPRC2022005)
10.12010/j.issn.1673-5846.2024.02.007
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