儿童急性肝衰竭(pediatric acute liver failure,PALF)是一种罕见、病情进展迅速的临床综合征,预后较差,病死率非常高.PALF病因复杂,临床表现多样且不典型,基于年龄的病因诊断、肝性脑病的早期识别、预防及精准的对因支持治疗对改善结局和预后至关重要.该文主要总结PALF诊断及治疗的相关进展,以期为临床工作提供帮助.[中国当代儿科杂志,2024,26(2):194-200]
Pediatric acute liver failure(PALF)is a rare and rapidly progressive clinical syndrome with a poor prognosis and significant mortality.The etiology of PALF is complex,and it presents with diverse and atypical clinical manifestations.Accurate diagnosis based on age-related factors,early recognition or prevention of hepatic encephalopathy,and precise supportive treatment targeting the underlying cause are crucial for improving outcomes and prognosis.This article provides a comprehensive review of recent research on the diagnosis and treatment of PALF,aiming to offer guidance for clinical practice.[Chinese Journal of Contemporary Pediatrics,2024,26(2):194-200]
明慧;何怡;许红梅
重庆医科大学附属儿童医院感染科/国家儿童健康与疾病临床研究中心/儿童发育疾病研究教育部重点实验室/儿童感染免疫重庆市重点实验室,重庆 400014
急性肝衰竭;诊断;治疗;儿童
Acute liver failure;Diagnosis;Treatment;Child
《中国当代儿科杂志》 2024 (002)
194-200 / 7
10.7499/j.issn.1008-8830.2309015
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