目的 观察宽胸气雾剂对冠心病经皮冠状动脉介入术(PCI)术后心绞痛患者临床疗效及生活质量的影响.方法 选取2022年12月—2023年9月在南方医院诊断为冠心病接受PCI治疗后仍有心绞痛的患者72例.将患者随机分为试验组和对照组,每组各36例.对照组给予常规药物治疗,试验组在常规药物治疗的基础上给予宽胸气雾剂舌下喷服,每次2喷,每日3次,连续喷服1个月.比较两组患者治疗前后的生活质量量表(SF-36)、西雅图心绞痛量表(SAQ)评分以及心绞痛缓解临床疗效.结果 最终试验组35例和对照组34例患者完成试验.与本组治疗前比较,两组治疗后心绞痛发作频次、心绞痛发作持续时间降低,SAQ各维度评分增高(P＜0.05);试验组治疗后SF-36各维度评分增高(P＜0.05);对照组治疗后SF-36躯体角色、躯体疼痛、一般健康状况、情绪角色评分增高(P＜0.05).与对照组比较,试验组治疗后心绞痛发作频次、心绞痛发作持续时间降低,SF-36和SAQ各维度评分增高(P＜0.05).两组心绞痛疗效比较,差异无统计学意义(P＞0.05),但试验组有升高趋势.结论 宽胸气雾剂能降低冠心病PCI术后心绞痛发作次数及持续时间,并改善患者的生活质量.
Objective To observe the effect of Kuanxiong Aerosol therapy on the clinical efficacy and quality of life of coronary heart disease patients with angina pectoris after percutaneous coronary intervention(PCI).Methods A total of 72 patients diagnosed with coronary heart disease and still had angina pectoris after PCI from December 2022 to September 2023 in Nanfang Hospital were inluded.The patients were randomly assigned to experimental group(36 cases)and control group(36 cases).The control group received routine treatment and the experimental group received sublingual spray of Kuanxiong Aerosol on the basis of routine treatment,2 sprays per time,3 times a day,for 1 continuous month.The scores of Short Form 36 Health Survey Questionaire(SF-36),Seattle Angina Questionnaire(SAQ),and clinical effect of angina pectoris relief between the 2 groups were compared before and after treatment.Results Totally 35 patients in the experimental group and 34 patients in the control group completed the experiment.Compared with before treatment,the frequency of angina attacks and the duration of angina attacks reduced,and the scores of each dimension of SAQ increased after treatment in the 2 groups(P＜0.05);the scores of each dimension of SF-36 increased after treatment in the experimental group(P＜0.05);the scores of SF-36 RP,BP,GH,RE increased after treatment in the control group(P＜0.05).Compared with the control group,the frequency of angina attacks and the duration of angina attacks in the experimental group decreased,and the scores of SF-36 and SAQ increased after treatment(P＜0.05).There was no significant difference in the curative effect of angina pectoris between the 2 groups(P＞0.05),but it has an increasing trend in experimental group.Conclusion Kuanxiong Aerosol could reduce the frequency and duration of of angina pectoris with coronary heart disease after PCI,and improve the quality of life of patients.
林志彬;邓运生;徐艳如;梁桂连;李崇信;曾庆春
南方医科大学南方医院心血管内科(广州 510515)
宽胸气雾剂;冠心病;心绞痛;生活质量;中成药;中西医结合;随机对照试验
Kuanxiong Aerosol;coronary heart disease;angina pectoris;quality of life;Chinese patent medicine;integrative medicine;randomized controlled trial
《中国中西医结合杂志》 2024 (002)
138-142 / 5
广州市科技计划项目(No.2023B01J1011)
10.7661/j.cjim.20231227.259
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