Small cell lung cancer(SCLC)is a highly malignant tumor with a very poor prognosis;therefore,more effective treatments are urgently needed for patients afflicted with the disease.In recent years,emerging molecular classifications based on key transcription factors of SCLC have provided more information on the tumor pathophysiology,metastasis,immune microenvironment,and acquired therapeutic resistance and reflected the intertumoral heterogeneity of the various SCLC phenotypes.Additionally,advances in genomics and single-cell sequencing analysis have further revealed the high intratumoral heterogeneity and plasticity of the disease.Herein,we review and summarize these recent lines of evidence and discuss the possible pathogenesis of SCLC.
Hanfei Guo;Wenqian Li;Ye Guo;Naifei Chen;Jiuwei Cui
Cancer Center,The First Hospital of Jilin University,Changchun,Jilin 130021,China
Small cell lung carcinoma;Molecular classification;Tumor heterogeneity;Drug resistance;Transcription factors;Ge-nomics;Phenotype;Prognosis
《中华医学杂志(英文版)》 2024 (002)
130-139 / 10
This work was supported by grants from the Jilin Scientific and Technological Development Program(CN)(No.20190303146SF)and General Program of National Natural Science Foundation of China(No.81874052).
10.1097/CM9.0000000000002693
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