目的 回顾性分析消脂合剂和阿托伐他汀治疗不同中医体质分型高脂血症的疗效差异.方法 选取 2020 年 5 月至2023 年 3 月在发现血脂异常并使用消脂合剂或阿托伐他汀治疗的患者 206 例,每组各 103 例,消脂合剂治疗组为中药组,阿托伐他汀治疗组为西药组,提取治疗前后血清总胆固醇(total cholesterol,TC)、三酰甘油(triglyceride,TG)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)及肝转氨酶,并计算非高密度脂蛋白胆固醇(non-high-density lipoprotein cholesterol,non-HDL-C).结果 在痰湿质中,中药组TC、TG、LDL-C及non-HDL-C均有明显下降(P<0.05);西药组TC、TG、non-HDL-C明显下降(P<0.05);其中中药组 TC、LDL-C、non-HDL-C 下降程度明显高于西药组(P<0.05).在气虚质中,中药组 TC、TG、LDL-C 及non-HDL-C均有明显下降(P<0.05);西药组TC、LDL-C、non-HDL-C明显下降(P<0.05);其中中药组non-HDL-C下降程度明显高于西药组(P<0.05);在血瘀质中,中药组各指标下降均不明显(P>0.05);西药组 TC、TG、LDL-C 及non-HDL-C 均有明显下降(P<0.05);其中中药组 TC、LDL-C、non-HDL-C 下降程度明显低于西药组(P<0.05);平和质中,中药组TC、non-HDL-C明显下降(P<0.05);西药组TC、LDL-C、non-HDL-C明显下降(P<0.05);中药组TC、LDL-C、non-HDL-C下降程度明显低于西药组(P<0.05).结论 消脂合剂治疗痰湿质及气虚质高脂血症的治疗效果优于阿托伐他汀,而对于血瘀质、平和质体质高脂血症的治疗效果不及阿托伐他汀.
Objective To analyze the effect of Xiaozhi Decoction in the treatment of hyperlipidemiain different classification of physical constitution in TCM.Methods We screened 206 patients with Hyperlipidemia in our hospital and had been treated with drugs during May 2020 to March 2023.Totally 103 patients in the TCM group were treated with Xiaozhi Decoction,103 patients in the western medicine group were treated with atorvastatin.Selected total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)and liver transaminase before and after a period of treatment.The non-high-density lipoprotein cholesterol(non-HDL-C)will be calculated,too.Results In the Phlegm-Dampness constitution,TC,TG,LDL-C and non-HDL-C decreased significantly all in the TCM group(P<0.05);TC,TG and non-HDL-C decreased significantly all in the western medicine group(P<0.05).The TCM group is superior to the western medicine group in TC,LDL-C,non-HDL-C(P<0.05).In the Qi-Deficiency constitution,TC,TG,LDL-C and non-HDL-C decreased significantly all in the TCM group(P<0.05);TC,LDL-C and non-HDL-C decreased significantly all in the western medicine group(P<0.05).The TCM group is superior to the western medicine group in non-HDL-C(P<0.05).In the Blood-Stasis constitution,TC,TG,LDL-C and non-HDL-C decreased significantly all in the western medicine group only(P<0.05).The western medicine group is superior to the TCM group in TC,LDL-C,non-HDL-C(P<0.05).In the Yin-Yang Harmony constitution,TC and non-HDL-C decreased significantly both in the TCM group(P<0.05).TC,LDL-C and non-HDL-C decreased significantly all in the western medicine group(P<0.05).The western medicine group is superior to the TCM group in TC,LDL-C,non-HDL-C(P<0.05).Conclusion Xiaozhi Decoction is superior to the the atorvastatin in the treatment of hyperlipidemia for the Phlegm-Dampness constitution and Qi-deficiency constitution groups.But it is not superior to the atorvastatin in the treatment of hyperlipidemia for the Blood-Stasis constitution and Yin-Yang Harmony constitution groups.
陈璐佳;刘宏飞;邓艳华;周建扬
浙江中医药大学附属宁波市中医院治未病中心,浙江宁波 315000
临床医学
消脂合剂;高脂血症;阿托伐他汀;中医体质分型;治疗效果
Decoction;Hyperlipidemia;Atorvastatin;Classification of physical constitution in TCM;Therapeutic effect
《中国现代医生》 2024 (002)
57-61 / 5
浙江省中医药科技计划项目(2021ZB253);浙江省宁波市卫生健康青年技术骨干人才培养专项(甬卫发[2022]97号);浙江省宁波市医学重点学科(2022-Z07);浙江省宁波市林刚名中医药专家传承工作室(甬卫发[2022]54号)
10.3969/j.issn.1673-9701.2024.02.014
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