枸杞叶黄酮泡腾片的配方优化及抗氧化活性研究OACSTPCD

This study aimed to optimize the formula of flavonoid effervescent tablets from Lycium barbarum leaves and evaluate its quality and antioxidant capacity,providing guidance for the functional development and utilization of L.barbarum leaves.The effervescent tablets of flavonoids from L.barbarum leaves were prepared by the semi-dry pressing method.The formulation of effervescent tablets was optimized by a single factor,Plackett-Burman,and Box-Behnken tests with the sensory score as the main evaluation index.The weight,hardness,disintegration time,foaming capacity,pH,and flavonoid content of L.barbarum leaf effervescent tablets were determined.The scavenging ability of DPPH radical,ABTS cationic radical,hydroxyl radical,and iron reduction ability were determined,evaluating its quality and antioxidant ability.The best formula of L.barbarum leaf flavonoids effervescent tablets was as follows:L.barbarum leaf fla-vonoids extract of 6％,polyvinylpyrrolidone of 1％,maltodextrin of 25％,magnesium stearate of 1.5％,stevioside of 0.9％,the starch of 9％,microcrystalline cellulose of 1.5％,disintegrating agent of 55.1％,and the proportion of citric acid-sodium bicarbonate of 1∶0.6.The average weight,hardness,disintegration time,foaming volume,pH,and flavonoid content of L.barbarum leaf effervescent tablets were(408±11)mg,(46.7±0.51)N,(217.8±2.07)s,(5.01±0.49)mL,4.80±0.004,and(47.93±0.05)mg/g,respectively.The IC50 of flavonoid effervescent tablets for DPPH free radicals,ABTS cationic radicals,and·OH were 0.77 mg/mL,2.01 mg/mL,and 1.10 mg/mL.When the mass concentration was 5 mg/mL,the iron reduction capacity of L.barbarum leaf flavonoid effervescent tablets was 28.85％of vitamin C.The technology of L.barbarum leaf flavonoid effervescent tablets is stable and feasible and has good antioxidant activity.