目的 探究支气管内置管泵药治疗厚壁空洞型肺结核的临床效果.方法 选取赣州市第五人民医院2019年10月至2020年12月收治的60例厚壁空洞型肺结核患者作为研究对象,按照抽签法分为观察组和对照组,每组各30例.对照组采用常规抗结核化疗治疗,观察组在常规抗结核基础上加用支气管内置管泵药治疗.比较两组的痰结核菌转阴率、空洞闭合率、复发率、不良反应.结果 两组治疗1个月后的痰结核菌转阴率比较,差异无统计学意义(P＞0.05);观察组治疗2个月后的痰结核菌转阴率高于对照组,差异有统计学意义(P＜0.05);而治疗6个月后,两组患者的痰结核菌均转阴,差异无统计学意义(P＞0.05);治疗1个月后,两组的空洞闭合率比较,差异无统计学意义(P＞0.05),而治疗2、6个月后,观察组空洞闭合率为90.00％、93.33％,均高于对照组的43.33％、56.67％,差异有统计学意义(P＜0.05);随访1年,两组的厚壁空洞型肺结核复发率比较,差异无统计学意义(P＞0.05);两组不良反应总发生率比较,差异无统计学意义(P＞0.05).结论 支气管内置管泵药治疗厚壁空洞型肺结核疗效显著,可促进痰找结核菌转阴,提高空洞闭合率,复发率低,无明显不良反应.
Objective To explore the clinical effect of endobronchial tube pump in the treatment of thick-wall cavity pulmonary tuberculosis.Methods A total of 60 patients with thick-wall cavity pulmonary tuberculosis admitted to the Fifth People's Hospital of Ganzhou from October 2019 to December 2020 were selected as the study objects,and they were divided into observation group and control group according to lottery method,with 30 cases in each group.The control group was treated with conventional antituberculosis chemotherapy,and the observation group was treated with endobronchial tube pump on the basis of conventional antituberculosis.The negative conversion rate of sputum tuberculosis,cavity closure rate,recurrence rate and adverse reactions were compared between the two groups.Results There was no statistically significant difference in the negative conversion rate of sputum tuberculosis between the two groups after 1 month of treatment(P＞0.05).After 2 months of treatment,the negative conversion rate of sputum tuberculosis in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).After 6 months of treatment,the sputum tuberculosis in the two groups turned negative,and the difference was not statistically significant(P＞0.05).After 1 month of treatment,there was no statistically significant difference in the cavity closure rate between the two groups(P＞0.05).After 2 and 6 months of treatment,the cavity closure rates of the observation group were 90.00％and 93.33％,which were higher than 43.33％and 56.67％of the control group,and the differences were statistically significant(P＜0.05).After 1 year of follow-up,there was no significant difference in the recurrence rate of thick-walled cavitary tuberculosis between the two groups(P＞0.05).There was no statistically significant difference in the total incidence of adverse reaction between the two groups(P＞0.05).Conclusion The effect of endobronchial tube pump drug in the treatment of thick-wall cavitary pulmonary tuberculosis is significant,which can promote the sputum to find tuberculosis bacteria to turn negative,improve the cavity closure rate,the recurrence rate is low,and there is no obvious adverse reaction.
蒋凛;卢飞燕;周静;彭平华;赖海斌;曾忠
江西省赣州市第五人民医院结核科,赣州市呼吸疾病重点实验室,赣州市呼吸病防治研究所,江西赣州 341000
临床医学
支气管内置管泵药;厚壁空洞型肺结核;空洞闭合率;复发率;不良反应
Endobronchial tube pump;Thick-wall cavity pulmonary tuberculosis;Cavity closure rate;Recurrence rate;Adverse reaction
《中国当代医药》 2024 (001)
31-34 / 4
江西省卫生健康委科技计划项目(20204693).
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