目的 探讨宣清导浊汤加减方联合血液透析治疗对老年慢性肾衰竭(CRF)患者肾功能、微炎症状态和毒素清除率的影响.方法 回顾性选取2019年10月—2022年10月我院收治的82例老年CRF患者,将其根据治疗方法分为联合组与单一组,每组41例.单一组仅采取血液透析治疗,联合组联合宣清导浊汤加减方治疗,对比两组患者治疗前后中医证候积分、毒素清除率、炎症因子变化.结果 治疗后,两组患者口淡不渴、肢体麻木、腰膝酸软、倦怠乏力、食少纳呆以及面色晦暗相关中医证候积分均降低,且联合组低于单一组(P＜0.05);治疗后两组患者血肌酐、尿素氮、血β2-微球蛋白均降低,联合组低于单一组(P＜0.05);治疗后两组患者白细胞介素-6、C-反应蛋白、肿瘤坏死因子-α炎性因子水平明显降低,且联合组更低(P＜0.05).两组在治疗期间均无不良反应.结论 宣清导浊汤加减方联合血液透析治疗老年CRF患者效果较佳,可通过降低机体炎症因子表达水平、提高毒素清除率来改善患者临床症状,且不会增加不良反应.
Objective To explore the effect of Xuanqing Daozhuo Decoction modified formula combined with hemodialysis treatment on renal function,micro inflammatory status,and toxin clearance rate in elderly patients with chronic renal failure(CRF).Methods Retrospectively,82 elderly CRF patients admitted to our hospital from October 2019 to October 2022 were selected and divided into a combination group and a single group according to the treatment methods,with 41 cases in each group.The single group was treated with hemodialysis only,and the combined group was treated with Xuanqing Daozhuo Decoction modified formula additionally.The changes of TCM syndrome scores,toxin clearance rate and inflammatory factors before and after treatment were compared between the two groups.Results After treatment,the scores of TCM syndroms including tasteless mouth and no thirst,numbness of limbs,soreness and weakness of waist and knee,fatigue,poor appetite and sluggish stomach were all decreased in 2 groups,and those in combined group were lower(P＜0.05).After treatment,serum creatinine,blood urea nitrogen and β2-microglobulin were decreased in 2 groups,and those in combined group were lower(P＜0.05).After treatment,the levels of interleukin-6,C-reactive protein and tumor necrosis factor-α inflammatory factors were significantly decreased in 2 groups,which were lower in combination group(P＜0.05).The two groups had no adverse effects during the treatment period.Conclusions Xuanqing Daozhuo Decoction modified formula and hemodialysis can improve the clinical symptoms of elderly patients with CRF,reduce the expression level of inflammatory factors in patients,and increase the clearance rate of toxins in patients,and does not increase the adverse effects.
赵茜颖;李俊
驻马店市中医院血液净化室(河南驻马店 463000)
宣清导浊汤加减方;血液透析;慢性肾衰竭;微炎症状态;毒素清除率
Xuanqing Daozhuo Decoction modified formula;hemodialysis;chronic renal failure;renal function;micro inflammatory state;toxin clearance rate
《广州医药》 2024 (001)
25-29 / 5
10.3969/j.issn.1000-8535.2024.01.004
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