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中西医结合治疗激素依赖型肾病综合征研究进展OACSTPCD

Research Progress in Treatment of Steroid-Dependent Nephrotic Syndrome with Integrative Medicine

中文摘要英文摘要

目前,临床治疗激素依赖型肾病综合征(steroid-dependent nephritic syndrome,SDNS)主要以激素、免疫抑制剂、细胞毒性药物等为主,仅有少数患者病情能够完全缓解,而联合中医药治疗可发挥增效减毒的作用,从而减少西药用量,缩短病程,降低不良反应,在减量或停药后稳定病情,防止复发.但中药方药相对固定,缺乏相关实验研究和统一标准,临床疗效悬殊,且中医病因病机、辨证分型、处方用药、疗效判定等缺乏统一标准,试验设计、疗效观察方法不够严谨,今后应结合大数据及现代医学研究方法,经过严密的科研设计,进行更多前瞻性、多中心的试验研究以证实中西医结合治疗方案的有效性,并在剂型、用药方式上进行创新,提高临床疗效.

Currently,the clinical treatment of steroid dependent nephrotic syndrome(SDNS)mainly relies on hormones,immuno-sup-pressants,cytotoxic drugs,etc.Only a few patients can completely alleviate their condition.Combined treatment with traditional Chinese medicine can play a role in increasing efficacy and reducing toxicity,thereby reducing the dosage of Western medicine,shortening the course of the disease,reducing adverse reactions,stabilizing the condition after dosage reduction or discontinuation,and preventing re-currence.Traditional Chinese medicine formulas are relatively fixed,lacking relevant experimental research and unified standards,resul-ting in significant differences in clinical efficacy.In addition,there is a lack of unified standards for TCM etiology and pathogenesis,syn-drome differentiation and classification,prescription medication,and efficacy assessment.The experimental design and efficacy observa-tion methods are not rigorous enough.In the future,we should combine big data and modern medical research methods,conduct rigorous scientific research design,and conduct more prospective research A multi-center experimental study is conducted to confirm the effec-tiveness of a combination of traditional Chinese and Western medicine treatment plan,and to innovate in dosage forms and medication methods to improve clinical efficacy.

苏雨田;吴垚;许正锦

北京中医药大学东直门医院厦门医院,福建 厦门 361000厦门市翔安区新店中心卫生院,福建 厦门 361000

中医学

激素依赖型肾病综合征;中西医结合;综述

hormone dependent nephrotic syndrome;integrative medicine;review

《中医学报》 2024 (001)

108-113 / 6

第五批全国中医临床优秀人才研修项目{国中医药人教函[2022]1号}

10.16368/j.issn.1674-8999.2024.01.018

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