论文检索
期刊
全部知识仓储预印本开放期刊机构
高级检索

百蕊草的研究进展OACSTPCD

Progress in Research of Bairuicao(Thesium chinense Turcz.)

中文摘要英文摘要

中药百蕊草具有清热解毒、消肿之功效,目前,相关研究主要涉及其生物特性、加工炮制、化学成分及其提取分离、药理作用4 个方面:百蕊草共有25 科82 种寄主,半寄生特性是其人工栽培的一大难点;百蕊草的炮制加工方法为洗净,切段后干燥;已分离鉴定出66 种化合物,其中黄酮类化合物 31 种,生物碱类 9 种,二萜类化合物 5 种,有机酸类 6 种,杂类化合物 15种;体内外研究表明,百蕊草具有抑菌、抗炎镇痛、抗氧化、抗癌等药理活性.尽管现代研究已经分离鉴定了包括黄酮、酚酸、二萜在内的多种成分,但已知的化合物数量十分有限,且对各类活性成分的生物合成、转运调控过程及分子机制也知之甚少,亦无官方药材质量控制标准.此外,野生百蕊草与栽培品种的功效是否一致缺少定论.故今后亟须进一步探讨百蕊草药材来源与生物活性成分和防治疾病作用的关系,推动百蕊草用药的规范化和科学化,为药材的质量控制和优良种植的选育提供参考.

The traditional Chinese medicine Bairuicao has the effects of clearing heat,detoxifying,and reducing swelling.Currently,re-lated research mainly involves four aspects:biological characteristics,processing and processing,chemical components and their extrac-tion and separation,and pharmacological effects.Bairuicao has a total of 25 families and 82 host species,and semi parasitic characteris-tics are a major difficulty in its artificial cultivation;The processing method of Bairuicao is to wash it,cut it into sections,and then dry it;66 compounds have been isolated and identified,including 31 flavonoids,9 alkaloids,5 diterpenoids,6 organic acids,and 15 miscella-neous compounds;In vitro and in vivo studies have shown that Bairuicao has pharmacological activities such as antibacterial,anti-in-flammatory,analgesic,antioxidant,and anticancer.Although modern research has isolated and identified various components,including flavonoids,phenolic acids,and diterpenes,the number of known compounds is very limited,and little is known about the biosynthesis,transport regulation,and molecular mechanisms of various active ingredients,as well as the lack of official quality control standards for medicinal materials.In addition,there is a lack of consensus on whether the efficacy of wild passion grass is consistent with that of culti-vated varieties.Therefore,it is urgent to further explore the relationship between the source,bioactive components,and disease preven-tion and treatment effects of the medicinal herb of Centella asiatica in the future,promote the standardization and scientificization of its medication,and provide reference for the quality control of the medicinal herb and the selection of excellent planting.

李佳珍;王一硕;杜紫微;王颖;张昌锋;李天爱

河南中医药大学药学院,河南 郑州 450046河南中医药大学药学院,河南 郑州 450046||河南省中药生产一体化工程技术研究中心,河南 郑州 450000

中医学

百蕊草;生物特性;加工炮制;化学成分;药理作用

Bairuicao(Thesium chinense Turcz.);biological characteristic;processing and processing;chemical composition;pharmaco-logical action

《中医学报》 2024 (001)

92-101 / 10

国家中医药管理局公益性行业专项项目(00104296);河南省科技创新杰出青年基金项目(184100510017);河南省高等学校重点科研项目(20A630020)

10.16368/j.issn.1674-8999.2024.01.016

评论

下载量:0
点击量:0