磷脂酰肌醇3 激酶(phosphatidylinositiol 3 kinase,PI3K)/蛋 白 激 酶 B(protein kinase B,PKB,又称AKT)/哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)信号通路在膝骨性关节炎(knee osteoarthritis,KOA)的形成、发展和治疗中起着关键作用,其在软骨增殖与凋亡、软骨下骨重塑和滑膜炎症中扮演重要角色.抑制PI3K/AKT/mTOR信号传导,能够促进自噬,减轻关节炎症反应,恢复关节稳态;激活PI3K/AKT/mTOR信号传导,可以促进软骨细胞增殖分化,减少凋亡.以中药单体和中药复方为研究对象,依据中药基于PI3K/AKT/mTOR信号通路分析其促进软骨细胞增殖、减少凋亡、抑制炎症反应、增强软骨细胞自噬、恢复关节稳态、减轻关节损伤等方面的机制,以期为KOA的临床治疗及基础研究提供思路.
The phosphatidylinositol 3-kinase(PI3K)/protein kinase B(PKB/AKT)/mammalian rapamycin target protein(mTOR)signaling pathway plays a crucial role in the formation,development,and treatment of knee osteoarthritis(KOA),It plays an important role in cartilage proliferation and apoptosis,subchondral bone remodeling,and synovitis.Inhibiting PI3K/AKT/mTOR signaling can pro-mote autophagy,alleviate joint inflammation,and restore joint homeostasis;Activating PI3K/AKT/mTOR signaling can promote chondro-cyte proliferation and differentiation,and reduce apoptosis.Based on the PI3K/AKT/mTOR signaling pathway analysis of traditional Chinese medicine,this study focuses on the promotion of chondrocyte proliferation,reduction of apoptosis,inhibition of inflammatory re-sponse,enhancement of chondrocyte autophagy,restoration of joint homeostasis,and reduction of joint injury.The aim is to provide ideas for the clinical treatment and basic research of KOA.
王笑甜;陈唤楠;孙福平;周友龙
河南中医药大学,河南 郑州 450046河南中医药大学第三临床医学院,河南 郑州 450008
中医学
膝骨性关节炎;中药;PI3K/AKT/mTOR信号通路
knee osteoarthritis;traditional Chinese medicine;PI3K/AKT/mTOR signaling pathway
《中医学报》 2024 (001)
84-91 / 8
河南省特色骨干学科建设项目(STG-ZYX02-202115)
10.16368/j.issn.1674-8999.2024.01.015
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