目的 观察苏沈九宝汤治疗支气管哮喘急性发作期的临床疗效和对Th1/Th2 因子的影响.方法 选取 2022 年 2 月至 2023 年 5 月于浙江中医药大学附属四省边际中医院诊治的 98 例支气管哮喘急性发作期患者,根据随机数字表法将其分为治疗组和对照组,每组各 49 例.对照组患者给予吸氧、雾化等常规治疗,治疗组患者在对照组基础上加用苏沈九宝汤.比较两组患者的临床疗效、中医证候积分、肺功能指标[第一秒用力呼气量(forced expiratory volume in first second,FEV1)、呼气流量峰值(peak expiratory flow,PEF)]和实验室指标[白细胞介素(interleukin,IL)-4、IL-13、γ干扰素(interferon-γ,IFN-γ)、免疫球蛋白E(immunoglobulin E,IgE)].结果 治疗组患者的总有效率显著高于对照组(χ2=9.287,P=0.010);治疗后,两组患者的中医证候积分、血清IL-4、IL-13、IgE水平均显著低于本组治疗前,FEV1、PEF、IFN-γ水平均显著高于本组治疗前(P<0.05),治疗组患者的中医证候积分、血清 IL-4、IL-13、IgE 水平均显著低于对照组,FEV1、PEF、IFN-γ 水平均显著高于对照组(P<0.05).结论 苏沈九宝汤治疗支气管哮喘急性发作,可显著提高临床疗效,降低患者的炎症因子水平,改善肺功能.
Objective To observe the clinical efficacy of Sushen Jiubao decoction in the treatment of acute exacerbation of bronchial asthma and its effect on Th1/Th2 factors.Methods Ninety-eight patients with acute exacerbation of bronchial asthma treated in Sishengbianji Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University from February 2022 to May 2023 were selected and divided into treatment group and control group according to random number table method,with 49 cases in each group.The control group was given conventional treatment such as oxygen inhalation and atomization,and the treatment group was additionally treated with Sushen Jiubao decoctionon based on the treatment of control group.The clinical efficacy,TCM syndrome score,pulmonary function indicators[forced expiratory volume in first second(FEV1),peak expiratory flow(PEF)],and laboratory indicators[interleukin(IL)-4,IL-13,interferon-γ(IFN-γ),immunoglobulin E(IgE)].Results The total effective rate of treatment group was significantly higher than that of control group(χ2=9.287,P=0.010).After treatment,the TCM syndrome scores,serum IL-4,IL-13 and IgE levels of two groups were significantly lower than before treatment,and FEV1,PEF and IFN-γ were significantly higher than before treatment(P<0.05).The TCM syndrome score,serum IL-4,IL-13 and IgE levels in treatment group were significantly lower than those in control group,and FEV1,PEF and IFN-γ were significantly higher than those in control group(P<0.05).Conclusion Sushen Jiubao decoction can significantly improve clinical efficacy,reduce the level of inflammatory factors,and improve pulmonary function in the treatment of acute exacerbation of bronchial asthma.
张毅平;廖小方;诸葛建成;楼炳恒
浙江中医药大学附属四省边际中医院重症医学科,浙江衢州 324002衢州市急救中心急救科,浙江衢州 324000
中医学
支气管哮喘;苏沈九宝汤;肺功能;Th1/Th2;急性发作期
Bronchial asthma;Sushen Jiubao decoction;Pulmonary function;Th1/Th2;Acute exacerbation
《中国现代医生》 2024 (001)
70-73 / 4
浙江中医药大学2021年附属医院科研专项(2021FSYYZQ13)
10.3969/j.issn.1673-9701.2024.01.017
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