目的 探讨在老年性脑梗死脑血流动力学研究中CT灌注成像(CTPI)的应用价值.方法 拟诊为脑梗死的患者50例,在发病1天内给予CTPI检查和16层CT平扫,对兴趣区脑血流量(CBF)、对比剂峰值时间(TTP)以及对比剂平均通过时间(MTT)进行测定,同时和对侧相应脑组织灌注参数进行对比;3～ 10天后全部患者均予MRI随访.结果 全部50例患者,20例患者经CT平扫检查发现缺血灶,47例患者经CTPI检查发现异常灌注.和对照区域相比,缺血区CBF显著降低、TTP、MTT显著延长(P＜0.05).结论 CTPI能准确反映脑梗死血流动力学状态,可为早期诊断和治疗老年性脑梗死提供科学依据.
Objective To investigate the value of CT perfusion imaging (CTPI) in the hemodynamic study on the senile cerebral infaction.Methods 50 patients doubted with cerebral infarction were tested by 16-slice CT plain scan and CTPI within 24 hours of onset.The cerebral blood flow (CBF),time to peak (TTP) and mean transit time (MTT) in region of interest (ROI) were determined and compared with the perfusion parameters in the contralateral corresponding area.All cases were followed-up with MRI after 3-10 days.Results Out of all cases,ischemia lesion was found on CT plain scanning in 20 patients and 47 patients showed abnormal peffusion on CTPI.In contrast to the control area,CBF was significantly reduced while MTT and TTP were significantly increased in research area (P ＜ 0.05).Conclusions CT perfusion imaging can accurately reveal the hemodynamic condition of cerebral infarction,which could provide a scientific basis for early diagnosis and treatment of the senile brain infarction.
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