新型低压氧舱治疗低频波动性感音神经性听力损失的临床前瞻性研究OA北大核心CSCDCSTPCD

Objective To investigate the clinical effects of new hypobaric oxygen chamber methods for low-frequency fluctuating sensorineural hearing loss. Methods Twenty cases with low-frequency fluctuating sensorineural hearing loss were included in the study, whose pure tone threshold and subjective symptoms degrees (ear stuffiness blocking, tinnitus, cranial tinnitus) were evaluated before and after exposed to hypobaric pressure in chamber. Treatment program had three cycles. In the first cycle, chamber pressure changed at the speed of 3 m/s from normal atmospheric pressure up to 2200 m altitude, about 78.6 kPa, maintain for 5 min, then down to 1100 m at 1 m/s speed. The cycle repeated twice. Finally, pressure returned to normal atmospheric pressure at the speed of 1m/s. All patients breathing pure oxygen continually with 150 L/h flow rate when the atmospheric pressures lower than 550 m altitude. Once every day, 5 times as a course of treatment. Patients with mild hearing loss were treated one course, and those with moderate hearing loss were treated two courses. There were 2 days rest between the two courses. Results All cases had no adverse reactions. Pure tone threshold showed that 55% (11/20) improved in hearing, in which 7 cases were cured and 4 cases were improved. The difference of hearing efficacy between mild and moderate hearing loss groups was statistically significant (P < 0.05). The total effective rate of ear stuffiness was 95% (19/20), in which 17 cases were cured and 2 cases improved. Total improved rate of tinnitus was 60%(12/20); Patients were followed up for four to six months. Only one case recurred with ear stuffiness. Then he accepted repeat hypobaric oxygen chamber treatment and cured again. Conclusions As a good non-invasive method, new hypobaric oxygen chamber can be an additional choice to treat low-frequency fluctuating sensorineural hearing loss, in particular improve ear stuffiness significantly.